Table 5 Results of stability study of the optimized gliclazide SMEDDS pellets
Time | Carr’s index (%) | Hausner’s ratio | Mean pellet size* (μm) | Drug content* | Drug release at 15 min* (%) |
|---|---|---|---|---|---|
0 | 3.04 | 1.031 | 969 ± 8.72 | 100.9 ± 2.69 | 93.00 ± 4.62 |
Product stored at accelerated condition of 40 °C/75% RH | |||||
3 months | 3.03 | 1.031 | 965.96 ± 9.14 | 99.9 ± 2.46 | 91.82 ± 3.96 |
6 months | 3.03 | 1.030 | 972.84 ± 10.72 | 99.1. ± 3.06 | 92.16 ± 4.27 |
Product stored at room temperature | |||||
3 months | 3.03 | 1.031 | 968.19 ± 8.65 | 100.2 ± 3.16 | 93.1 ± 3.05 |
6 months | 3.04 | 1.031 | 971.08 ± 6.19 | 99.9 ± 1.47 | 90.19 ± 4.27 |