Groups | T wave inverted rats (%) | HR (bpm) | QT (s) | QTc (s) | QRS (s) |
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Control | 0 (0%)b | 335 ± 31b | 0.042 ± 0.01b | 0.11 ± 0.023b | 0.019 ± 0.002b |
MP (150 mg/kg) | 0 (0%)b | 341 ± 69b | 0.044 ± 0.007b | 0.13 ± 0.029 b | 0.028 ± 0.004b |
ISO | 8 (80%)a | 458 ± 20a | 0.1 ± 0.02a | 0.3 ± 0.055a | 0.05 ± 0.01a |
MP (150 mg/kg) + ISO | 1 (10%)b | 344 ± 21b | 0.051 ± 0.012b | 0.15 ± 0.013b | 0.031 ± 0.006b |
- Rats were pretreated with MP (150 mg/kg, p.o) three times per week at alternating days for 2 weeks and then 2 consecutive doses of ISO separated by 24 h (85 mg/kg, s.c) on the 13th and 14th days; data are expressed as mean ± SD (n = 10), except for T wave inversions which are indicated as %
- a, bSignificantly different from control or ISO groups respectively at P < 0.05 using one-way ANOVA followed by Tukey as a post hoc test