Table 1 Composition of zotepine loaded solid lipid nanoparticles
Ingredients (% w/v) | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
Zotepine (mg) | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
Dynasan®118 | 1.0 | – | – | 2.0 | – | – | – |
Dynasan®114 | – | 1.0 | – | – | 2.0 | – | – |
Compritol ATO 888 | – | – | 1.0 | – | – | 2.0 | – |
Soylecithin | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | – |
Poloxamer 188 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | – |
Na CMC* | – | – | – | – | – | – | 0.05 |
Water (mL) | QS 10 | QS 10 | QS 10 | QS 10 | QS 10 | QS 10 | QS 10 |