Table 5 Effects of repeated oral administration (35 days) of 50, 100, and 200 mg/kg EEPM fruits, normal control, diabetic control, drug control (glibenclamide-0.5 mg/kg) groups on serum creatinine, urea, lipid profile, and liver profile in STZ-induced diabetic rats

Creatinine (mg/dL)

0.2 ± 0.1

0.7 ± 0.9

0.4 ± 0.4**

0.6 ± 0.8*

0.5 ± 0.7

0.5 ± 0.6

Urea (mg/dL)

26.6 ± 0.7

42.5 ± 2.6

32.3 ± 2.9**

38 ± 3.2**

37.2 ± 2.8*

34.5 ± 3*

HDL cholesterol (mg/dL)

55.3 ± 1.4

18.3 ± 3.8

44.6 ± 2.6**

29.1 ± 4.5*

34.2 ± 3.7*

39.7 ± 3*

LDL cholesterol (mg/dL

88 ± 0.7

153.7 ± 4.7

90.7 ± 5.1**

120.3 ± 4.3*

112.6 ± 3.7*

103.3 ± 4.8**

Cholesterol (mg/dL

59.9 ± 1.8

107.3 ± 3.4

69.3 ± 2.6**

85.2 ± 4.1*

77.7 ± 3.8*

73.4 ± 3.2**

Triglyceride (mg/dL

64.2 ± 3.5

100.5 ± 5.7

76.3 ± 3.3*

92 ± 5

88 ± 6.3*

84 ± 5.6*

AST (U/L)

44.8 ± 2.2

93.2 ± 4.9

69.5 ± 3.3**

80.3 ± 2.9*

77.2 ± 4.03*

77 ± 3.7*

ALT (U/L)

21.3 ± 1.8

32.5 ± 4.1

25.9 ± 2.7**

30.5 ± 3**

30 ± 4.4*

28.7 ± 3.2**

ALP (U/L)

89.9 ± 2.8

158 ± 5.3

131.5 ± 6.8**

146 ± 5.3*

144 ± 5.1*

139 ± 4.6*

T.BIL (mg/dL)

0.5 ± 0.4

1.3 ± 0.9

0.8 ± 0.5*

1.2 ± 0.8*

1 ± 0.7*

0.9 ± 0.6**

T.Prot (g/dL)

6.8 ± 0.5

5 ± 1.9

6 ± 0.7**

5.5 ± 1*

5.8 ± 0.9*

5.9 ± 0.7**