Molecule | GI absorption | BBB permeant | Pgp substrate | CYP1A2 inhibitor | CYP2C19 inhibitor | CYP2C9 inhibitor | CYP2D6 inhibitor | CYP3A4 inhibitor |
---|---|---|---|---|---|---|---|---|
Molecule 1 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 2 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 3 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 4 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 5 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 6 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 7 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 8 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 9 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 10 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 11 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 12 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 13 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 14 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 15 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 16 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 17 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 18 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 19 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 20 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 21 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 22 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 23 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 24 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 25 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 26 | High | No | Yes | No | Yes | Yes | Yes | Yes |
Molecule 27 | High | No | No | No | Yes | Yes | Yes | Yes |
Molecule 28 | Low | No | Yes | No | Yes | Yes | Yes | Yes |