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Table 4 Boiled-egg and CYP isoforms inhibition

From: Computational virtual screening and structure-based design of some epidermal growth factor receptor inhibitors

Molecule GI absorption BBB permeant Pgp substrate CYP1A2 inhibitor CYP2C19 inhibitor CYP2C9 inhibitor CYP2D6 inhibitor CYP3A4 inhibitor
Molecule 1 High No Yes No Yes Yes Yes Yes
Molecule 2 High No Yes No Yes Yes Yes Yes
Molecule 3 High No No No Yes Yes Yes Yes
Molecule 4 High No No No Yes Yes Yes Yes
Molecule 5 High No No No Yes Yes Yes Yes
Molecule 6 High No Yes No Yes Yes Yes Yes
Molecule 7 High No No No Yes Yes Yes Yes
Molecule 8 High No No No Yes Yes Yes Yes
Molecule 9 High No No No Yes Yes Yes Yes
Molecule 10 High No Yes No Yes Yes Yes Yes
Molecule 11 High No No No Yes Yes Yes Yes
Molecule 12 High No No No Yes Yes Yes Yes
Molecule 13 High No No No Yes Yes Yes Yes
Molecule 14 High No No No Yes Yes Yes Yes
Molecule 15 High No No No Yes Yes Yes Yes
Molecule 16 High No No No Yes Yes Yes Yes
Molecule 17 High No Yes No Yes Yes Yes Yes
Molecule 18 High No Yes No Yes Yes Yes Yes
Molecule 19 High No Yes No Yes Yes Yes Yes
Molecule 20 High No Yes No Yes Yes Yes Yes
Molecule 21 High No Yes No Yes Yes Yes Yes
Molecule 22 High No Yes No Yes Yes Yes Yes
Molecule 23 High No Yes No Yes Yes Yes Yes
Molecule 24 High No Yes No Yes Yes Yes Yes
Molecule 25 High No Yes No Yes Yes Yes Yes
Molecule 26 High No Yes No Yes Yes Yes Yes
Molecule 27 High No No No Yes Yes Yes Yes
Molecule 28 Low No Yes No Yes Yes Yes Yes