Table 4 Predicted ADMET properties of the selected compounds
SN | GI absorption | BBB permeant | Bioavailability score | CYP-substrate/inhibitor | ||||
|---|---|---|---|---|---|---|---|---|
5 | Low | No | 0.55 | 3A4 | 1A2 | 2C19 | 2C9 | 2D6 |
9 | Low | No | 0.55 | Yes | Yes | Yes | No | Yes |
10 | Low | No | 0.55 | Yes | Yes | Yes | No | Yes |
11 | Low | No | 0.55 | Yes | Yes | Yes | No | Yes |
Vem. | Low | No | 0.55 | Yes | Yes | Yes | No | Yes |