Table 1 Composition of tenofovir and maraviroc bigel formulations

Hydrogel

Hyaluronic acid (% w/w)

5

2.5

5

2.5

Tenofovir (%w/w)

1

1

1

1

Organogel

Tween 80 (% v/w)

38

38

43

43

Labrafac (% v/w)

19

19

22

22

Oil (% v/w)

21

21

21

21

Water (% v/w)

22

22

14

14

Propylparaben (% w/w)

0.01

0.01

0.01

0.01

Maraviroc (% w/w)

0.1

0.1

0.1

0.1

Bigel

Organogel to hydrogel ratio

1: 1

3:2

2: 3

3:2