Antidiabetic and antiulcerative potential of Garcinia lanceifolia Roxb. bark

Future Journal of Pharmaceutical Sciences

Table 2 Results of acute toxicity studies (LD₅₀ calculation) of HAEGL conducted using AOT425 Statistical Program

Test sequence	Animal ID	Dose (mg/kg)	Short-term result	Long-term result
1	HAEGL1	175	O	O
2	HAEGL2	550	O	O
3	HAEGL3	1750	O	O
4	HAEGL4	5000	X	X
5	HAEGL5	1750	O	O
6	HAEGL6	5000	O	O
7	HAEGL7	5000	O	O
8	HAEGL8	5000	O	X
Legend: (X = died, O = survived)
Summary of long term results
Dose (mg/kg bw)		Animals survived	Animals died	Total
175		1	0	1
550		1	0	1
1750		2	0	2
5000		2	2	4
All doses		6	2	8

Statistical program suggested that estimated LD₅₀ = 5000 (the one dose with partial response). 95% PL confidence interval is 2045 to Greater than 20,000