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Table 4 Antidepressant activity of different extracts of A. trilobata on tail suspension test in mice

From: Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Group (mg/kg) Immobile time Inhibition (%)
Control (10 mL/kg) 186.0 ± 1.69 -
Fluoxetine (20) 82.33 ± 1.19c 55.74
MEATL 200 158.33 ± 4.01c 14.87
MEATL 400 106.67 ± 3.47c 42.65
NFATL 200 144.0 ± 4.36c 22.58
NFATL 400 78.67 ± 1.33c 57.71
MEATS 200 113.0 ± 2.65c 39.24
MEATS 400 82.0 ± 2.08c 55.91
NFATS 200 118.33 ± 4.91c 36.38
NFATS 400 82.67 ± 3.71c 55.55
  1. ns non-significant, MEATL methanol extract of A. trilobata leaves, NFATL n-hexane fraction of A. trilobata leaves, MEATS methanol extract of A. trilobata stem, NFATS n-hexane fraction of A. trilobata stem
  2. The statistical analysis followed by one-way analysis of variance (Dunnett’s test) compared to the negative control (1% Tween-80) using GraphPad Prism version 8.4
  3. The results were expressed in mean ± SEM (standard error mean)
  4. cp < 0.001 considered as statistically significant