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Future Journal of Pharmaceutical Sciences

Table 4 Antidepressant activity of different extracts of A. trilobata on tail suspension test in mice

From: Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model

Group (mg/kg)

Immobile time

Inhibition (%)

Control (10 mL/kg)

186.0 ± 1.69

-

Fluoxetine (20)

82.33 ± 1.19c

55.74

MEATL 200

158.33 ± 4.01c

14.87

MEATL 400

106.67 ± 3.47c

42.65

NFATL 200

144.0 ± 4.36c

22.58

NFATL 400

78.67 ± 1.33c

57.71

MEATS 200

113.0 ± 2.65c

39.24

MEATS 400

82.0 ± 2.08c

55.91

NFATS 200

118.33 ± 4.91c

36.38

NFATS 400

82.67 ± 3.71c

55.55

  1. ns non-significant, MEATL methanol extract of A. trilobata leaves, NFATL n-hexane fraction of A. trilobata leaves, MEATS methanol extract of A. trilobata stem, NFATS n-hexane fraction of A. trilobata stem
  2. The statistical analysis followed by one-way analysis of variance (Dunnett’s test) compared to the negative control (1% Tween-80) using GraphPad Prism version 8.4
  3. The results were expressed in mean ± SEM (standard error mean)
  4. cp < 0.001 considered as statistically significant
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