Table 2 NOACs—indications and doses [7]
From: NOACs: an emerging class of oral anticoagulants-a review article
Drug | Non-valvular atrial fibrillation (to prevent stroke and systemic embolism) | Venous thromboembolism prophylaxis | DVT and PE | Others |
|---|---|---|---|---|
Dabigatran | 150 mg twice daily | 110 mg 1 to 4 h after completion of surgery and establishment of haemostasis, or the initial dose of 220 mg after haemostasis is achieved and continued for 10–14 days | 150 mg twice daily | |
Rivaroxaban | 20 mg once daily with the evening meal | 10 mg once daily for 31–39 days | 15 mg twice daily with food for 21 days followed by 20 mg once daily with food | CAD: 2.5 mg twice daily with low-dose aspirin; heparin-induced thrombocytopenia: 15 mg daily with food for 21 days followed by 20 mg once daily |
Apixaban | 5 mg twice daily | 2.5 mg twice daily beginning 12–24 h post-operatively | 10 mg twice daily for 7 days followed by 5 mg twice daily | Heparin-induced thrombocytopenia:10 mg twice daily for 7 days followed by 5 mg twice daily |
Edoxaban | 60 mg once daily | Patient weight > 60 kg, 60 mg once daily, and ≤ 60 kg,30 mg once daily |