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Table 1 Independent variables, dependent variables and constraints for central composite design

From: Development of nitazoxanide-loaded colon-targeted formulation for intestinal parasitic infections: centre composite design-based optimization and characterization

  Levels
Independent variables Low (− 1) Medium (0) High (+ 1)
X1 = chitosan (% w/v) 2.75 3 3.25
X2 = NaTPP (% w/v) 1.75 2 2.25
Constraints applied on dependent variables
  Independent variables Dependent variables
X1: chitosan (% w/v) X2: NaTPP (% w/v) Y1: particle size (um) Y2: percentage yield (%) Y3: entrapment efficiency (%)
Constraints In range In range In range Maximize Maximize
Importance +++ +++ ++++ ++++ ++++