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Table 5 Results of the application of proposed methods for Brintellix® tablets

From: A novel stability-indicating method for determination of a new antidepressant effect of vortioxetine in a pharmaceutical formulation by using RP-HPLC

Sample no. Amount found, mg
RP-HPLC Derivative spectrophotometry
237.7 nm 257.2 nm
1 10.07 9.51 10.26
2 10.00 9.51 10.26
3 10.23 9.51 9.91
4 9.87 9.73 10.26
5 10.11 9.51 10.62
Mean value*, mg 10.06 9.55 10.26
Labeled amount, mg 10.00 10.00 10.00
p: 0,05 C.L, 10.06 ± 0.16 9.55 ± 0.18 10.26 ± 0.32
RSD 1.33 1.52 2.45
  1. *Value = average ± ts/√N (N = 5 and at 95% confidence level)