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Table 13 Freeze-thaw stability for bexarotene (at − 70 °C ± 15 °C and − 30 °C ± 10)

From: Development and validation of bexarote by bioanalytical methods using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

QC ID − 70 °C ± 15 °C − 30 °C ± 10 °C
LQC FT4 HQC FT4 LQC FT4 HQC FT4
Actual concentration (ng/mL) 2.7800 263.2320 2.7800 263.2320
Calculated concentrations (ng/mL) 2.7739 277.0834 2.9870 270.1236
2.7193 264.5538 2.8392 272.0022
2.9684 272.1494 2.6626 263.9169
2.6266 269.6594 2.7717 276.9206
2.9136 268.7336 2.9150 266.3756
2.8143 271.7938 2.7318 262.5824
Mean 2.80268 270.66223 2.81788 268.65355
SD 0.125448 4.165615 0.120119 5.407447
%CV 4.48 1.54 4.26 2.01
%nominal 100.82 102.82 101.36 102.06