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Table 13 Freeze-thaw stability for bexarotene (at − 70 °C ± 15 °C and − 30 °C ± 10)

From: Development and validation of bexarote by bioanalytical methods using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

QC ID

− 70 °C ± 15 °C

− 30 °C ± 10 °C

LQC FT4

HQC FT4

LQC FT4

HQC FT4

Actual concentration (ng/mL)

2.7800

263.2320

2.7800

263.2320

Calculated concentrations (ng/mL)

2.7739

277.0834

2.9870

270.1236

2.7193

264.5538

2.8392

272.0022

2.9684

272.1494

2.6626

263.9169

2.6266

269.6594

2.7717

276.9206

2.9136

268.7336

2.9150

266.3756

2.8143

271.7938

2.7318

262.5824

Mean

2.80268

270.66223

2.81788

268.65355

SD

0.125448

4.165615

0.120119

5.407447

%CV

4.48

1.54

4.26

2.01

%nominal

100.82

102.82

101.36

102.06