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Table 8 Intra-batch precision and accuracy of bexarotene

From: Development and validation of bexarote by bioanalytical methods using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

QC ID LOQQC LQC INTQC MQC HQC
Actual concentration (ng/mL) 1.0500 2.7800 25.2700 131.6160 263.2320
Calculated concentration (ng/mL) (MTR-BA-LC-MS/MS-19) PA–01
(06 Apr 2015)
1.1639 2.9471 25.8272 135.3234 277.1292
1.1622 2.8307 26.0325 128.5281 276.5622
1.0975 2.9013 25.3157 131.3295 272.8455
1.0866 2.8823 25.3351 132.7338 267.9314
1.1758 3.0348 26.1218 136.8898 264.0381
1.1043 2.9858 26.5157 133.2429 277.9904
Mean 1.13172 2.93033 25.85800 133.00792 272.74947
SD 0.039664 0.073957 0.469270 2.947768 5.662107
%CV 3.50 2.52 1.81 2.22 2.08
%nominal 107.78 105.41 102.33 101.06 103.62
Calculated concentration (ng/mL) (MTR-BA-LC-MS/MS-19) PA–02
(07 Apr 2015)
1.0709 2.7864 26.1883 134.5485 270.4602
1.0005 2.8122 25.8356 134.5475 274.3989
0.8813 2.8064 25.3888 138.3150 266.9063
1.0456 2.8642 25.3942 133.0021 272.3938
1.1056 2.9071 25.5199 132.3109 266.4461
1.0615 2.8626 25.6117 136.5209 273.7517
Mean 1.02757 2.83982 25.65642 134.87415 270.72617
SD 0.079461 0.045549 0.308551 2.228847 3.417745
%CV 7.73 1.60 1.20 1.65 1.26
%Nominal 97.86 102.15 101.53 102.48 102.85