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Future Journal of Pharmaceutical Sciences
Fig. 3 | Future Journal of Pharmaceutical Sciences

Fig. 3

From: Comparative evaluation of intranasally delivered quetiapine loaded mucoadhesive microemulsion and polymeric nanoparticles for brain targeting: pharmacokinetic and gamma scintigraphy studies

Fig. 3

 Mean quetiapine concentration versus time profile after intranasal administration of quetiapine loaded nanoparticles (QNP), mucoadhesive microemulsion (QMME), microemulsion (QME) and drug solution (DS) and intravenous administration of quetiapine loaded nanoparticles(QNP) and microemulsion (QME) in rat: (a) Brain profile showing highest concentration of quetiapine in the rat brain following intranasal administration of QMME (p<0.0243) compared to intravenous QME and QNP respectively; and (b) Plasma profile showing highest concentration of quetiapine in rat plasma following intravenous administration of QME and QNP compared to intranasal formulations. (Data represents mean ± SD, n=4)

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