Table 1 Extraction for the use of different solvent details
S. no. | Solvent name | Appearance of solution, clear solution (yes/no) | Observations |
|---|---|---|---|
1 | Methanol | No | Observed Bortezomib peak response was very low. |
2 | Ethanol | No | Observed Bortezomib peak response was very low. |
3 | Dimethyl formamide | Yes | Bortezomib peak response was not detected. |
4 | Dimethyl sulfoxide | Yes | Bortezomib peak response was not detected. |
5 | Chloroform | No | Observed Bortezomib peak response was very low. |
6 | Ethyl acetate | No | Observed Bortezomib peak response was very low. |
7 | Water | Yes | Further, chloroform added to the aqueous clear solution and extracted the Bortezomib. Observed Bortezomib peak response was found not satisfactory. |
8 | Water | Yes | Further, ethyl acetate added to the aqueous clear solution and extracted the Bortezomib. Observed Bortezomib peak response was found satisfactory. |