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Table 1 Physical constants, antimycobacterial activity, and docking score of target compounds (4a–o)

From: Design and synthesis of new 3-((7-chloroquinolin-4-yl)amino)thiazolidin-4-one analogs as Mycobacterium tuberculosis DNA gyrase inhibitors

Code Ar M.P. (°C) Yield (%) MIC (μM) Docking score
4a 4-Fluorobenzaldehyde 282 85 6.25 − 4.395
4b 2-Chlorobenzaldehyde 280 61 6.25 − 3.891
4c 4-Chlorobenzaldehyde 150 67 6.25 − 3.943
4d 2,3-Dichlorobenzaldehyde 300 73 12.5 − 3.223
4e 2,4-Dichlorobenzaldehyde 308 77 1.56 − 3.945
4f 4-Bromobenzaldehyde 140 81 3.12 − 4.291
4g 3-Bromo,4-fluorobenzaldehyde 294 66 1.56 − 3.771
4h p-anisaldehyde 260 62 3.12 − 4.437
4i 3,4-Dimethoxybenzaldehyde 130 60 3.12 − 3.553
4j 3,4,5-Trimethoxybenzaldehyde 280 50 12.5 − 3.637
4k 4-Nitrobenzaldehyde 300 61 6.25 − 3.573
4l 4-Hydroxybenzaldehyde 312 62 12.5 − 4.533
4m 4-Cyanobenzaldehyde 304 58 12.5 − 4.439
4n p-dimethylaminobenzaldehyde 195 60 1.56 − 3.14
4o Thiophene-2-carbaldehyde 330 67 1.56 − 4.496
Ethambutol 1.56 − 6.245
Pyrazinamide 3.12 − 3.61
Ciprofloxacin 3.12 − 5.913