Table 2 Composition of minitablet (weight of each minitablet 15 mg)
Formulation | Quantity drug and excipient (mg) in each solid dispersion formulation | Number of tablets for 60 mg dose | |||||
|---|---|---|---|---|---|---|---|
Nimodipine | Compritol ATO 888 | Gelucire 43/01 | Gelucire 39/01 | Precirol ATO 5 | Sylysia 350 | ||
F1 | 7.5 | 3.75 | – | – | – | 3.75 | 8 |
F2 | 5 | 5 | – | – | – | 5 | 12 |
F3 | 3.75 | 5.625 | – | – | – | 5.625 | 16 |
F4 | 3 | 6 | – | – | – | 6 | 20 |
F5 | 2.5 | 6.25 | – | – | – | 6.25 | 24 |
F6 | 7.5 | – | 3.75 | – | – | 3.75 | 8 |
F7 | 5 | – | 5 | – | – | 5 | 12 |
F8 | 3.75 | – | 5.625 | – | – | 5.625 | 16 |
F9 | 3 | – | 6 | – | – | 6 | 20 |
F10 | 2.5 | – | 6.25 | – | – | 6.25 | 24 |
F11 | 7.5 | – | – | 3.75 | – | 3.75 | 8 |
F12 | 5 | – | – | 5 | – | 5 | 12 |
F13 | 3.75 | – | – | 5.625 | – | 5.625 | 16 |
F14 | 3 | – | – | 6 | – | 6 | 20 |
F15 | 2.5 | – | – | 6.25 | – | 6.25 | 24 |
F16 | 7.5 | – | – | – | 3.75 | 3.75 | 8 |
F17 | 5 | – | – | – | 5 | 5 | 12 |
F18 | 3.75 | – | – | – | 5.625 | 5.625 | 16 |
F19 | 3 | – | – | – | 6 | 6 | 20 |
F20 | 2.5 | – | – | – | 6.25 | 6.25 | 24 |