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Table 21 Robustness study results of acetone

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 1.3 8.53 96548 1.3
2.5 1.4 7.77 95214 1.2
2.7 1.5 6.99 93245 1.4
Column oven temperature (± 5 °C) 35 °C 1.2 8.61 97451 1.2
40 °C 1.4 7.77 95214 1.2
45 °C 1.3 6.98 96548 1.3
Vial oven temperature (± 5 °C) 85 °C 1.3 7.69 91024 1.3
90 °C 1.4 7.77 95214 1.2
95 °C 1.4 7.72 94752 1.1