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Table 23 Robustness study results of dichloromethane

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 2.9 10.13 13982 1.3
2.5 3.2 9.21 12547 1.4
2.7 2.8 8.29 11857 1.5
Column oven temperature (± 5 °C) 35 °C 3.1 10.14 12478 1.2
40 °C 3.2 9.21 12547 1.4
45 °C 3.1 8.34 13415 1.3
Vial oven temperature (± 5 °C) 85 °C 3.4 9.20 12145 1.1
90 °C 3.2 9.21 12547 1.4
95 °C 3.2 9.19 13245 1.2