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Table 24 Robustness study results of N-hexane

From: Determination of residual solvents in paclitaxel by headspace gas chromatography

Parameter System conditions Percentage RSD for peak area (n = 6) Retention time Plate count Tailing factor
Flow rate (± 0.2 mL/min) 2.3 3.2 12.45 79584 1.0
2.5 3.4 11.31 78987 1.3
2.7 3.5 10.19 72142 1.1
Column oven temperature (± 5 °C) 35 °C 3.2 12.47 79658 1.1
40 °C 3.4 11.31 78987 1.3
45 °C 3.6 10.21 77415 1.2
Vial oven temperature (± 5 °C) 85 °C 3.0 11.30 79584 1.3
90 °C 3.4 11.31 78987 1.3
95 °C 3.3 11.32 80154 1.2