Table 4 Results of system suitability study
From: Determination of residual solvents in paclitaxel by headspace gas chromatography
Solvent name | Retention time | Percentage RSD for area count of six replicate injection of standard | Tailing factor | Theoretical plates | Resolution |
|---|---|---|---|---|---|
Methanol | 4.93 | 2.5 | 1.0 | 58451 | NA |
Ethanol | 6.65 | 1.6 | 1.1 | 78485 | 10.3 |
Acetone | 7.77 | 1.4 | 1.2 | 95214 | 5.8 |
Isopropyl alcohol | 8.25 | 2.0 | 1.0 | 32548 | 2.2 |
Dichloromethane | 9.21 | 3.2 | 1.4 | 12547 | 4.2 |
N-Hexane | 11.31 | 3.4 | 1.3 | 78987 | 8.0 |
Ethyl acetate | 13.79 | 1.7 | 1.1 | 65848 | 12.0 |
Tetrahydrofuran | 14.12 | 2.8 | 1.0 | 97845 | 2.9 |
DIPEA | 17.45 | 3.5 | 1.2 | 98751 | 32.1 |
Acceptance Criteria | For information | NMT 15.0 | NMT 2.0 | NLT 2000 | NLT 1.5 |