Table 5 In silico toxicity profiles of some designed inhibitors
Some newly designed inhibitors | Referenced drug | |||||
|---|---|---|---|---|---|---|
Toxicity properties | 39b | 39c | 39f | 39g | 39m | Lumateperone |
AMES toxicity | Yes | Yes | Yes | Yes | No | Yes |
hERG I inhibitor | No | No | No | No | No | No |
Carcinogenicity | No | No | No | No | No | No |
Hepatotoxicity | No | Yes | Yes | Yes | No | Yes |
Skin sensitization | No | No | No | No | No | No |