Parameters | RP-HPLC | |
---|---|---|
LVD | TDF | |
Linearity | ||
Range (μg/mL) | 10–50 | |
Determination coefficient (r2) | 0.995 | 0.996 |
Accuracy | ||
Mean percent recovery (%) | 99.19–100.05 | 99.21–100.01 |
RSD % | 00.20–0.72 | 0.10–0.83 |
Precision | ||
Intra-day precision (RSD %) | 0.26–1.64 | 0.10–1.15 |
Inter-day precision (RSD %) | 0.35–0.44 | 0.40–0.68 |
Repeatability (RSD %) | 0.57 | 0.71 |
Sensitivity | ||
LOD (μg) | 0.10 | 0.25 |
LOQ (μg | 0.32 | 0.45 |
Robustness | Robust | |
Ruggedness | ||
Analysts-I (mean ± SD) | 99.24 ± 0.14 | 99.45 ± 0.19 |
Analysts-II (mean ± SD) | 99.95 ± 0.25 | 99.69 ± 0.27 |
Specificity | Specific | |
% Assay of drugs | 99.78 ± 0.24 | 99.50 ± 0.17 |