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Table 4 Arrhenius plot and activation parameters of bedaquiline in different pH solutions

From: Evaluation of physicochemical stability and degradation kinetics of bedaquiline in hydrolytic solutions of different pH

Acid Activation r Ea (kJ/mol) ∆H ∆S
0.1N ln k= −500.4x−1.181 0.98 4.16 6.43 −54.93
1.0N ln k= −457.3x−1.007 0.90 3.80 6.07 −53.62
2.0N ln k= −400.1x−1.196 0.94 3.33 5.60 −51.89
Alkali Activation r Ea (kJ/mol) ∆H ∆S
0.1N ln k = −424.5x−1.430 0.99 3.52 2.274 −39.71
1.0N ln k = −337.0x−1.601 0.99 2.80 2.273 −39.71
2.0N ln k = −336.8x−1.293 0.96 2.80 2.273 −39.71