Table 5 Evaluation of stability of OCNIG
S. No. | Characterization of OCNIG | Freshly prepared (initial) | After 3 months | ||
|---|---|---|---|---|---|
25 ± 2 °C/65 ± 5% | 40 ± 2 °C/75 ± 5% RH | Refrigerated condition (4 ± 2 °C) | |||
1 | Clarity | Clear, smooth and homogenous | Clear, smooth and homogenous | Clear, smooth and homogenous | Clear, smooth and homogenous |
2 | pH | 6.8 ± 0.1 | 6.75 ± 0.1 | 6.78 ± 0.1 | 6.7 ± 0.2 |
3 | Drug Content (%) | 98.43 ± 0.023 (GLB) 97.89 ± 0.026 (ATN) | 97.33 ± 0.012 (GLB) 97.21 ± 0.016 (ATN) | 97.12 ± 0.01 (GLB) 97.01 ± 0.012 (ATN) | 97.09 ± 0.02 (GLB) 96.21 ± 0.04 (ATN) |
4 | Entrapment Efficiency (%) | 97.34 ± 0.034(GLB) 96.89 ± 0.015 (ATN) | 97.04 ± 0.015 (GLB) 95.99 ± 0.025 (ATN) | 97.34 ± 0.012 (GLB) 95.25 ± 0.055 (ATN) | 96.04 ± 0.013 (GLB) 94.89 ± 0.04 (ATN) |
5 | Vesicle size (nm) | 120.45 ± 3.87 | 120.08 ± 2.65 | 124.08 ± 2.65 | 130.08 ± 2.65 |