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Table 5 Evaluation of stability of OCNIG

From: Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation

S. No. Characterization of OCNIG Freshly prepared (initial) After 3 months
25 ± 2 °C/65 ± 5% 40 ± 2 °C/75 ± 5% RH Refrigerated condition (4 ± 2 °C)
1 Clarity Clear, smooth and homogenous Clear, smooth and homogenous Clear, smooth and homogenous Clear, smooth and homogenous
2 pH 6.8 ± 0.1 6.75 ± 0.1 6.78 ± 0.1 6.7 ± 0.2
3 Drug Content (%) 98.43 ± 0.023 (GLB)
97.89 ± 0.026 (ATN)
97.33 ± 0.012 (GLB)
97.21 ± 0.016 (ATN)
97.12 ± 0.01 (GLB)
97.01 ± 0.012 (ATN)
97.09 ± 0.02 (GLB)
96.21 ± 0.04 (ATN)
4 Entrapment Efficiency (%) 97.34 ± 0.034(GLB)
96.89 ± 0.015 (ATN)
97.04 ± 0.015 (GLB)
95.99 ± 0.025 (ATN)
97.34 ± 0.012 (GLB)
95.25 ± 0.055 (ATN)
96.04 ± 0.013 (GLB)
94.89 ± 0.04 (ATN)
5 Vesicle size (nm) 120.45 ± 3.87 120.08 ± 2.65 124.08 ± 2.65 130.08 ± 2.65