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Table 7 Pharmacokinetic parameters of ATN and GLB in rabbits

From: Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation

S. No Pharmaco-kinetic parameters Marketed formulation OCPG formulation
GLB ATN GLB ATN
1 Tmax (h) 4 ± 0.53 4 ± 0.08 13.00 ± 0.24 13.00 ± 0.05
2 Cmax (ng/ml) 251.58 ± 10.52 177.62 ± 10.14 151.76 ± 12.15 127.64 ± 10.06
3 AUC0–t (ng h/ml) 2226.88 ± 2.31 1422.6 ± 2.58 2930.21 ± 3.15 2838.94 ± 1.91
4 AUC0–∞ (ng h/ml) 2357.93 ± 1.24 1576.48 ± 4.24 3362.37 ± 2.22 3122.55 ± 1.35
5 t1/2 9.54 ± 0.07 8.45 ± 0.04 16.945 ± 1.24 14.786 ± 1.23
6 MRT 12.543 11.759 17.087 15.432
7 F% 134.30 180.32