Table 7 Pharmacokinetic parameters of ATN and GLB in rabbits
S. No | Pharmaco-kinetic parameters | Marketed formulation | OCPG formulation | ||
|---|---|---|---|---|---|
GLB | ATN | GLB | ATN | ||
1 | Tmax (h) | 4 ± 0.53 | 4 ± 0.08 | 13.00 ± 0.24 | 13.00 ± 0.05 |
2 | Cmax (ng/ml) | 251.58 ± 10.52 | 177.62 ± 10.14 | 151.76 ± 12.15 | 127.64 ± 10.06 |
3 | AUC0–t (ng h/ml) | 2226.88 ± 2.31 | 1422.6 ± 2.58 | 2930.21 ± 3.15 | 2838.94 ± 1.91 |
4 | AUC0–∞ (ng h/ml) | 2357.93 ± 1.24 | 1576.48 ± 4.24 | 3362.37 ± 2.22 | 3122.55 ± 1.35 |
5 | t1/2 | 9.54 ± 0.07 | 8.45 ± 0.04 | 16.945 ± 1.24 | 14.786 ± 1.23 |
6 | MRT | 12.543 | 11.759 | 17.087 | 15.432 |
7 | F% | – | – | 134.30 | 180.32 |