Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Future Journal of Pharmaceutical Sciences

Table 6 Apparent permeability coefficients (P_app) (× 10⁻⁶ cm/s) of atorvastatin in the everted ileum of healthy rat small intestine (n = 3)

Time (min)	Ileum
Time (min)	Atorvastatin-treated rats	Atorvastatin + verapamil-treated rats	Atorvastatin + Q-Cu complex-treated rats	Atorvastatin + Q-Co complex-treated rats	Atorvastatin + Q-Ni complex-treated rats
10	0.040 ± 0.003	0.041 ± 0.002	0.023 ± 0.001	0.022 ± 0.002	0.023 ± 0.0006
30	0.046 ± 0.004	0.036 ± 0.003	0.019 ± 0.001	0.015 ± 0.001	0.018 ± 0.001
45	0.085 ± 0.021	0.033 ± 0.002	0.018 ± 0.001	0.009 ± 0.001	0.013 ± 0.001
60	0.169 ± 0.122	0.032 ± 0.003*	0.016 ± 0.001**	0.007 ± 0.0001**	0.005 ± 0.0002**

All values expressed as mean ± SD. *p < 0.01 highly significant, **p < 0.001 very highly significant, compared to atorvastatin control