Future Journal of Pharmaceutical Sciences

Table 16 Bioactivities of Tezacaftor and its metabolites based on the drug likeness score were calculated using Molinspiration tool

From: A rapid RP-HPLC method for the simultaneous estimation of Ivacaftor and Tezacaftor and in silico study of their metabolitic products

Name	GPCR ligand	ICM	KI	NRL	PI	EI
Tezacaftor	0.3	− 0.06	− 0.27	0.08	0.34	0.17
Tezacaftor M1	0.21	− 0.28	0.09	0.03	0.21	0.20
Tezacaftor M2	0.25	− 0.29	0.08	0.06	0.17	0.10

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