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Table 16 Bioactivities of Tezacaftor and its metabolites based on the drug likeness score were calculated using Molinspiration tool

From: A rapid RP-HPLC method for the simultaneous estimation of Ivacaftor and Tezacaftor and in silico study of their metabolitic products

Name

GPCR ligand

ICM

KI

NRL

PI

EI

Tezacaftor

0.3

− 0.06

− 0.27

0.08

0.34

0.17

Tezacaftor M1

0.21

− 0.28

0.09

0.03

0.21

0.20

Tezacaftor M2

0.25

− 0.29

0.08

0.06

0.17

0.10