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Table 3 Solubility results of GLZ, GLZ–DNS, GLZ–PDA, and GLZ–LPN in a different dissolution media

From: Cocrystallization of gliclazide with improved physicochemical properties

  GLZ GLZ–LPN GLZ–PDA GLZ–DNS
Aqueous medium 0.3471 ± 0.06 0.3636 ± 0.121 0.531 ± 0.090 0.526 ± 0.212
6.8 PBS 1.096 ± 0.154 2.591 ± 0.966 2.23 ± 0.777 1.633 ± 0.233
7.4 PBS 0.911 ± 0.58 3.750 ± 0.127 4.093 ± 0.240 5.785 ± 0.105
0.1 N HCl 1.672 ± 0.172 2.428 ± 0.549 2.220 ± 0.391 3.734 ± 1.225
  1. Note: GLZ gliclazide, DNS 3,5-dinitrosalicylic acid, PDA 2,6-pyridinedicarboxylic acid, LPN L-proline