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Table 3 Solubility results of GLZ, GLZ–DNS, GLZ–PDA, and GLZ–LPN in a different dissolution media

From: Cocrystallization of gliclazide with improved physicochemical properties

 

GLZ

GLZ–LPN

GLZ–PDA

GLZ–DNS

Aqueous medium

0.3471 ± 0.06

0.3636 ± 0.121

0.531 ± 0.090

0.526 ± 0.212

6.8 PBS

1.096 ± 0.154

2.591 ± 0.966

2.23 ± 0.777

1.633 ± 0.233

7.4 PBS

0.911 ± 0.58

3.750 ± 0.127

4.093 ± 0.240

5.785 ± 0.105

0.1 N HCl

1.672 ± 0.172

2.428 ± 0.549

2.220 ± 0.391

3.734 ± 1.225

  1. Note: GLZ gliclazide, DNS 3,5-dinitrosalicylic acid, PDA 2,6-pyridinedicarboxylic acid, LPN L-proline