Table 4 Pharmacokinetic parameters of pure GLZ and prepared cocrystals
From: Cocrystallization of gliclazide with improved physicochemical properties
Parameters | Pure GLZ | GLZ–DNS | GLZ–PDA | GLZ–LPN |
|---|---|---|---|---|
Cmax (ng/mL) | 263.73 ± 4.28 | 621.31 ± 3.42 | 462.24 ± 1.89 | 346.21 ± 2.51 |
Tmax (h) | 3 ± 0.00 | 2 ± 0.00 | 2.5 ± 0.00 | 3 ± 0.00 |
AUC0–24 (h ng/mL) | 3372.79 ± 17.97 | 6153.32 ± 312.88 | 5193.53 ± 182.37 | 4501.16 ± 238.55 |
t1/2 (h) | 9.47 ± 0.25 | 7.86 ± 0.43 | 8.99 ± 0.31 | 9.12 ± 0.57 |
MRT (h) | 13.64 ± 0.05 | 11.34 ± 0.07 | 12.97 ± 0.06 | 13.16 ± 0.04 |