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Table 4 Pharmacokinetic parameters of pure GLZ and prepared cocrystals

From: Cocrystallization of gliclazide with improved physicochemical properties

Parameters Pure GLZ GLZ–DNS GLZ–PDA GLZ–LPN
Cmax (ng/mL) 263.73 ± 4.28 621.31 ± 3.42 462.24 ± 1.89 346.21 ± 2.51
Tmax (h) 3 ± 0.00 2 ± 0.00 2.5 ± 0.00 3 ± 0.00
AUC0–24 (h ng/mL) 3372.79 ± 17.97 6153.32 ± 312.88 5193.53 ± 182.37 4501.16 ± 238.55
t1/2 (h) 9.47 ± 0.25 7.86 ± 0.43 8.99 ± 0.31 9.12 ± 0.57
MRT (h) 13.64 ± 0.05 11.34 ± 0.07 12.97 ± 0.06 13.16 ± 0.04
  1. Note: GLZ gliclazide, DNS 3,5-dinitrosalicylic acid, PDA 2,6-pyridinedicarboxylic acid, LPN L-proline