Table 1 Layout of central composite design batches (*average ± SD, n = 3)
Run | X1 (Conc of PVP, %w/v) | X2 (SAS Ratio) | Y1 (Particle size, nm)* | Y2 (%CDR10)* | ||
|---|---|---|---|---|---|---|
CCD1 | 0 | 0 | 311.00 ± 4.00 | 87.39 ± 3.89 | ||
CCD2 | + 1.41 | 0 | 352.67 ± 3.79 | 79.71 ± 4.84 | ||
CCD3 | − 1.41 | 0 | 414.67 ± 6.03 | 67.65 ± 5.95 | ||
CCD4 | + 1 | + 1 | 324.67 ± 6.51 | 84.98 ± 4.62 | ||
CCD5 | 0 | + 1.41 | 302.00 ± 10.58 | 88.95 ± 4.99 | ||
CCD6 | − 1 | − 1 | 464.33 ± 5.51 | 58.41 ± 5.07 | ||
CCD7 | 0 | − 1.41 | 484.33 ± 6.51 | 56.29 ± 4.79 | ||
CCD8 | + 1 | − 1 | 383.67 ± 6.51 | 72.97 ± 4.60 | ||
CCD9 | − 1 | + 1 | 341.33 ± 4.16 | 83.59 ± 4.56 | ||
LER NCs | 0.56 | 27 | 308.18 ± 10.56 | 87.50 ± 1.17 | ||
Independent variables | Levels | |||||
− α(− 1.41) | − 1 | 0 | + 1 | + α(+ 1.41) | ||
X1 = Concentration of PVP | 0.15 | 0.25 | 0.5 | 0.75 | 0.85 | |
X2 = SAS ratio | 6 | 10 | 20 | 30 | 34 | |