Table 11 Mass balance and peak purity study of DOX
Stress conditions | % Degradation* | Purity angle | Purity threshold | % Assay | Mass balance | RT of degradant (min) |
|---|---|---|---|---|---|---|
Acid | 9.75 | 0.317 | 1.082 | 89.51 | 99.26 | 2.018, 3.917 |
Alkaline | 15.15 | 0.198 | 0.501 | 83.83 | 98.98 | 1.422, 3.287 |
Neutral | 5.8 | 0.227 | 0.691 | 93.31 | 99.11 | 2.584 |
Oxidative | 12.25 | 0.358 | 0.828 | 87.74 | 99.99 | 3.496, 12.311 |
Photolytic | 0 | 0.496 | 0.956 | 98.62 | 98.62 | – |
Thermal | 0 | 0.101 | 0.472 | 99.01 | 99.01 | – |