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Table 2 Experimental runs for Box-Behnken design

From: Design expert as a statistical tool for optimization of 5-ASA-loaded biopolymer-based nanoparticles using Box Behnken factorial design

Formulation Factor A Factor B Factor C Response 1 Response 2
  Concentration of chitosan
% w/v
Concentration of CMI
% w/v
Concentration of drug
% w/v
Particle size
nm±SD
Entrapment efficiency %
nm±SD
1 0.2 (+ 1) 0.08 (0) 0.5 (+ 1) 199.25±1.2 79.20±2.2
2 0.15(0) 0.08 (0) 0.3 (0) 179.41±2.2 72.32±3.3
3 0.1 (−1) 0.08 (0) 0.5 (+ 1) 160.36±3.0 59.36±4.5
4 0.1 (−1) 0.06 (−1) 0.3 (0) 15,535±3.6 66.14±5.2
5 0.15 (0) 0.1 (+ 1) 0.5 (+ 1) 188.85±4.5 64.25±5.0
6 0.1 (−1) 0.08 (0) 0.1 (−1) 151.62±1.5 66.22±3.6
7 0.2 (+ 1) 0.06 (−1) 0.3 (0) 208.55±1.8 86.50±1.4
8 0.2 (+ 1) 0.1 (+ 1) 0.3 (0) 192.55±1.5 77.45±1.5
9 0.15 (0) 0.1 (+ 1) 0.1 (−1) 191.27±2.0 71.48±2.0
10 0.1 (−1) 0.1 (+ 1) 0.3 (0) 174.22±2.8 55.34±3.5
11 0.15 (0) 0.06 (−1) 0.5 (+ 1) 193.32±4.2 73.38±1.8
12 0.15 (0) 0.08 (0) 0.3 (0) 180.20±5.2 73.49±1.6
13 0.2 (+ 1) 0.08 (0) 0.1 (−1) 184.18±2.5 88.58±1.0
14 0.15 (0) 0.08 (0) 0.3 (0) 178.42±1.8 72.25±2.2
15 0.15 (0) 0.06 (−1) 0.1 (−1) 179.34±3.6 82.54±2.6