Table 3 Result and methods of antidiabetic and antioxidant activity

Annona cherimola

Leaves

Aqueous extract at 300 mg/kg displayed substantial decrease the level of glucose in blood.

Alloxan induced male albinos Sprague-Dawley rats.

[59, 60]

Juice, Skin, Flesh

Flesh extract at 98.085 Trolox Equivalents per 100 g dose showed maximum scavenging activity.

Oxygen radical absorbance capacity (ORAC) assay

[60]

Annona squamosa

Leaves

Aqueous leaf extract revealed significant Antihyperglycemic effect

Streptozotocin-nicotinamide type 2 diabetic rats (250 and 500 mg/kg)

[61]

• IC_{50 =} 40 μg/ml

• IC₅₀ = 60 μg/ml

• IC₅₀ = 110 μg/ml

• IC₅₀ = 115 μg/ml

• ABTS

• Nitric oxide

• DPPH

• Superoxide

[62]

Annona macroprophyllata

Leave

With a low IC₅₀ (1.18 μg/ml) repressed the activity of yeast alpha-glucosidase and reduce blood glucose level.

Streptozotocin induced diabetic male Wistar rats.

[63]

Annona muricata

Leaves

The aqueous extract showed significant blood glucose lowering effect at dose 100 and 200 mg/kg.

Streptozotocin induced diabetic albino Wistar rats.

[64]

Leaves

Ethanol extract of Annona muricata showed significant antioxidant activity in in vitro model.

DPPH, ABTS, nitric oxide, super oxide, hydroxy radical and lipid peroxidation

[65]

Annona reticulata

Leaves

Ethyl acetate fraction from hydroalcoholic extract of Annona reticulata at dose 100 mg/kg reduced blood glucose level significantly.

Streptozotocin induced hyperglycemic Wistar albino rats

[66]

–

Antioxidant activity not reported.

–

–

Annona crassifora

Peel, Seeds, Pulp

Ethanol and aqueous extract express in vitro antioxidant potential.

DPPH and lipid peroxidation assay.

[67]

–

Not reported Antidiabetic activity.

–

–

Annona coriacea

Seeds, Pulp

• DPPH and beta carotene bleaching test showed free radical scavenging activity of 31.53%, 51.59% respectively in in vitro model.

DPPH, Beta-carotene bleaching and ABTS radical cation.

[68]

Annona carcans

Pulp, Seeds, Leaves

Potent in vitro antioxidant activity was shown by pulp, leaves and seeds extract and fractions.

DPPH, ABTS, and beta-carotene/linoleic acid methods.

[21]

–

Antidiabetic activity not reported.

–

Annona senegalensis

Leaves

Aqueous leave extract showed potent antioxidant activity in in vitro model

DPPH, H₂O₂, superoxide ion, ABTS and ferric ion models

[69]

–

Antidiabetic activity not reported.

–