Skip to main content

Table 10 ANOVA analysis for trospium chloride ER tablets DOE batches

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Response Source Sum of squares df Mean square F value p value Remarks
Percent drug release at 2 h (acid stage) Model 2027.00 7 289.57 62.76  < 0.0001 significant
Residual 50.75 11 4.61    
Cor Total 2212.95 19     
Percent drug release at 5 h (Buffer stage) Model 3980.94 7 568.71 79.95  < 0.0001 significant
Residual 78.25 11 7.11    
Cor Total 4267.20 19     
Percent drug release at 11 h (Buffer stage) Model 2317.00 8 289.63 66.20  < 0.0001 significant
Residual 43.75 10 4.37    
Cor Total 2405.75 19     
Percent drug release at 20 h (Buffer stage) Model 137.06 9 15.23 25.50  < 0.0001 significant
Residual 5.37 9 0.5972    
Cor Total 142.55 19     
  1. df degrees of freedom, Cor Total Corrected total sum of squares; α: 0.05