Table 11 The regression equation obtained for percent drug release
Response | Regression equation for coded factors | R2 | Adjusted R2 | Predicted R2 |
|---|---|---|---|---|
Percent drug release at 2 h (acid stage) | = + 14.75 − 4.25A − 5.13B + 6.00C + 3.63AB − 3.25AC − 2.37BC + 4.12ABC | 0.9756 | 0.9600 | 0.9309 |
Percent drug release at 5 h (Buffer stage) | = + 34.19 − 2.44A − 8.19B + 11.44C + 2.44AB − 0.9375AC − 5.44BC + 2.94ABC | 0.9807 | 0.9685 | 0.9332 |
Percent drug release at 11 h (Buffer stage) | = + 63.50 − 7.25A − 4.25B + 8.50C + 0.00D + 0.5AC + 0.25AD − 0.25CD + 1.25ACD | 0.9815 | 0.9666 | 0.9335 |
Percent drug release at 20 h (Buffer stage) | = + 96.81 − 2.69A − 0.0625B + 0.187C − 0.187D − 0.062AB − 0.687AD − 0.0625BD + 0.687CD − 0.5625ABD | 0.9623 | 0.9245 | 0.8065 |