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Table 11 The regression equation obtained for percent drug release

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Response Regression equation for coded factors R2 Adjusted R2 Predicted R2
Percent drug release at 2 h (acid stage)  =  + 14.75 − 4.25A − 5.13B + 6.00C + 3.63AB − 3.25AC − 2.37BC + 4.12ABC 0.9756 0.9600 0.9309
Percent drug release at 5 h (Buffer stage)  =  + 34.19 − 2.44A − 8.19B + 11.44C + 2.44AB − 0.9375AC − 5.44BC + 2.94ABC 0.9807 0.9685 0.9332
Percent drug release at 11 h (Buffer stage)  =  + 63.50 − 7.25A − 4.25B + 8.50C + 0.00D + 0.5AC + 0.25AD − 0.25CD + 1.25ACD 0.9815 0.9666 0.9335
Percent drug release at 20 h (Buffer stage)  =  + 96.81 − 2.69A − 0.0625B + 0.187C − 0.187D − 0.062AB − 0.687AD − 0.0625BD + 0.687CD − 0.5625ABD 0.9623 0.9245 0.8065
  1. (A) Polyethylene oxide (mg), (B) cellulose acetate (% ratio), (C) polyethylene glycol 3350 (% ratio) and (D) orifice diameter (mm)