Skip to main content

Table 8 Evaluation parameters of core and push–pull osmotic pump (PPOP) tablets of trospium chloride

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Batch Evaluation parameters of core tablets Parameters of developed osmotic pump tablets
Weight (mg) Diameter (mm) Thickness (mm) Hardness (kg/cm2) Friability (%) Weight (mg) Diameter (mm) Thickness (mm) Drug content (%)
TSP1 396 ± 5 10.32 6.42 ± 0.01 14.40 ± 2 0.05 452 ± 5 10.80 ± 0.01 6.75 ± 0.01 98.65 ± 2
TSP2 392 ± 4 10.32 6.45 ± 0.02 14.32 ± 1 0.05 455 ± 6 10.83 ± 0.02 6.78 ± 0.02 101.36 ± 1
TSP3 446 ± 6 10.33 6.82 ± 0.01 17.54 ± 2 0.2 500 ± 3 10.86 ± 0.02 6.71 ± 0.02 100.54 ± 0.5
TSP4 345 ± 3 10.31 6.11 ± 0.02 15.69 ± 2 0.1 402 ± 8 10.78 ± 0.01 6.84 ± 0.01 97.85 ± 2
TSP5 350 ± 7 10.32 6.18 ± 0.03 16.98 ± 1 0.13 409 ± 9 10.81 ± 0.01 6.71 ± 0.01 102.12 ± 0.05
TSP6 348 ± 3 10.33 6.15 ± 0.02 18.32 ± 1 0.11 402 ± 3 10.75 ± 0.02 6.78 ± 0.02 98.42 ± 1
TSP7 445 ± 4 10.31 6.81 ± 0.01 16.58 ± 1 0.05 501 ± 7 10.82 ± 0.02 6.70 ± 0.02 97.27 ± 1
TSP8 449 ± 9 10.32 6.86 ± 0.01 15.74 ± 2 0.1 499 ± 4 10.86 ± 0.01 6.76 ± 0.01 100.95 ± 0.05
TSP9 345 ± 5 10.32 6.12 ± 0.02 14.52 ± 2 0.12 405 ± 9 10.80 ± 0.01 6.67 ± 0.01 99.47 ± 0.05
TSP10 445 ± 4 10.33 6.88 ± 0.02 18.65 ± 1 0.12 505 ± 10 10.81 ± 0.02 6.75 ± 0.01 97.36 ± 2
TSP11 351 ± 3 10.31 6.10 ± 0.01 16.21 ± 1 0.14 404 ± 3 10.78 ± 0.02 6.68 ± 0.01 102.11 ± 1
TSP12 445 ± 7 10.32 6.90 ± 0.01 15.45 ± 2 0.12 503 ± 5 10.82 ± 0.01 6.81 ± 0.02 100.34 ± 1
TSP13 397 ± 5 10.32 6.42 ± 0.02 13.20 ± 2 0.16 448 ± 4 10.81 ± 0.01 6.80 ± 0.03 98.67 ± 2
TSP14 447 ± 8 10.32 6.87 ± 0.02 16.00 ± 2 0.14 508 ± 5 10.79 ± 0.02 6.74 ± 0.02 98.28 ± 3
TSP15 394 ± 4 10.33 6.41 ± 0.01 18.10 ± 1 0.14 454 ± 8 10.80 ± 0.01 6.70 ± 0.03 97.73 ± 2
TSP16 443 ± 3 10.33 6.89 ± 0.01 14.36 ± 2 0.13 507 ± 7 10.84 ± 0.02 6.75 ± 0.02 101.36 ± 2
TSP17 346 ± 6 10.31 6.13 ± 0.02 14.49 ± 3 0.11 402 ± 4 10.82 ± 0.02 6.69 ± 0.01 96.35 ± 1
TSP18 444 ± 4 10.31 6.91 ± 0.02 15.00 ± 1 0.09 509 ± 5 10.77 ± 0.01 6.82 ± 0.02 100.84 ± 2
TSP19 346 ± 5 10.32 6.18 ± 0.01 17.75 ± 1 0.05 401 ± 9 10.83 ± 0.01 6.85 ± 0.02 98.91 ± 1
TSP20 348 ± 3 10.32 6.11 ± 0.01 16.00 ± 2 0.12 405 ± 9 10.81 ± 0.02 6.74 ± 0.03 99.35 ± 2
  1. Values are expressed as mean ± S.E.M; n = 3