Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Gundu, Ramakanth; Pekamwar, Sanjay; Shelke, Santosh; Kulkarni, Deepak; Shep, Santosh

doi:10.1186/s43094-021-00311-6

Future Journal of Pharmaceutical Sciences

Table 8 Evaluation parameters of core and push–pull osmotic pump (PPOP) tablets of trospium chloride

From: Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Batch	Evaluation parameters of core tablets					Parameters of developed osmotic pump tablets
Batch	Weight (mg)	Diameter (mm)	Thickness (mm)	Hardness (kg/cm²)	Friability (%)	Weight (mg)	Diameter (mm)	Thickness (mm)	Drug content (%)
TSP1	396 ± 5	10.32	6.42 ± 0.01	14.40 ± 2	0.05	452 ± 5	10.80 ± 0.01	6.75 ± 0.01	98.65 ± 2
TSP2	392 ± 4	10.32	6.45 ± 0.02	14.32 ± 1	0.05	455 ± 6	10.83 ± 0.02	6.78 ± 0.02	101.36 ± 1
TSP3	446 ± 6	10.33	6.82 ± 0.01	17.54 ± 2	0.2	500 ± 3	10.86 ± 0.02	6.71 ± 0.02	100.54 ± 0.5
TSP4	345 ± 3	10.31	6.11 ± 0.02	15.69 ± 2	0.1	402 ± 8	10.78 ± 0.01	6.84 ± 0.01	97.85 ± 2
TSP5	350 ± 7	10.32	6.18 ± 0.03	16.98 ± 1	0.13	409 ± 9	10.81 ± 0.01	6.71 ± 0.01	102.12 ± 0.05
TSP6	348 ± 3	10.33	6.15 ± 0.02	18.32 ± 1	0.11	402 ± 3	10.75 ± 0.02	6.78 ± 0.02	98.42 ± 1
TSP7	445 ± 4	10.31	6.81 ± 0.01	16.58 ± 1	0.05	501 ± 7	10.82 ± 0.02	6.70 ± 0.02	97.27 ± 1
TSP8	449 ± 9	10.32	6.86 ± 0.01	15.74 ± 2	0.1	499 ± 4	10.86 ± 0.01	6.76 ± 0.01	100.95 ± 0.05
TSP9	345 ± 5	10.32	6.12 ± 0.02	14.52 ± 2	0.12	405 ± 9	10.80 ± 0.01	6.67 ± 0.01	99.47 ± 0.05
TSP10	445 ± 4	10.33	6.88 ± 0.02	18.65 ± 1	0.12	505 ± 10	10.81 ± 0.02	6.75 ± 0.01	97.36 ± 2
TSP11	351 ± 3	10.31	6.10 ± 0.01	16.21 ± 1	0.14	404 ± 3	10.78 ± 0.02	6.68 ± 0.01	102.11 ± 1
TSP12	445 ± 7	10.32	6.90 ± 0.01	15.45 ± 2	0.12	503 ± 5	10.82 ± 0.01	6.81 ± 0.02	100.34 ± 1
TSP13	397 ± 5	10.32	6.42 ± 0.02	13.20 ± 2	0.16	448 ± 4	10.81 ± 0.01	6.80 ± 0.03	98.67 ± 2
TSP14	447 ± 8	10.32	6.87 ± 0.02	16.00 ± 2	0.14	508 ± 5	10.79 ± 0.02	6.74 ± 0.02	98.28 ± 3
TSP15	394 ± 4	10.33	6.41 ± 0.01	18.10 ± 1	0.14	454 ± 8	10.80 ± 0.01	6.70 ± 0.03	97.73 ± 2
TSP16	443 ± 3	10.33	6.89 ± 0.01	14.36 ± 2	0.13	507 ± 7	10.84 ± 0.02	6.75 ± 0.02	101.36 ± 2
TSP17	346 ± 6	10.31	6.13 ± 0.02	14.49 ± 3	0.11	402 ± 4	10.82 ± 0.02	6.69 ± 0.01	96.35 ± 1
TSP18	444 ± 4	10.31	6.91 ± 0.02	15.00 ± 1	0.09	509 ± 5	10.77 ± 0.01	6.82 ± 0.02	100.84 ± 2
TSP19	346 ± 5	10.32	6.18 ± 0.01	17.75 ± 1	0.05	401 ± 9	10.83 ± 0.01	6.85 ± 0.02	98.91 ± 1
TSP20	348 ± 3	10.32	6.11 ± 0.01	16.00 ± 2	0.12	405 ± 9	10.81 ± 0.02	6.74 ± 0.03	99.35 ± 2

Values are expressed as mean ± S.E.M; n = 3

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