Skip to main content

Table 5 Analgesic effect of the investigated extracts of M. dispermus leaves and stem barks on tail immersion test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group Pain reaction time in seconds (% MPE)
Pretreatment 30 min 60 min 90 min 120 min
Control 3.57 ± 0.43 4.69 ± 0.35 (9.77%) 4.32 ± 0.35 (6.58%) 4.65 ± 0.40 (9.42%) 4.14 ± 0.34 (5.01%)
Morphine sulfate (10 mg/kg) 3.96 ± 0.30 11.06 ± 0.35*** (64.31%) 12.52 ± 0.44*** (77.51%) 14.24 ± 0.57*** (93.15%) 14.36 ± 0.17*** (94.18%)
MDML (200 mg/kg) 3.88 ± 0.33 5.65 ± 0.22 (15.90%) 8.95 ± 0.33*** (45.62%) 10.08 ± 0.47*** (55.78%) 13.07 ± 0.42*** (82.66%)
MDML (400 mg/kg) 3.54 ± 0.46 7.95 ± 0.46*** (38.47%) 10.31 ± 0.38*** (59.10%) 13.07 ± 0.64*** (83.12%) 13.77 ± 0.50*** (89.28%)
MDHL (200 mg/kg) 3.92 ± 0.49 8.08 ± 0.52*** (37.52%) 8.77 ± 0.62*** (43.76%) 8.40 ± 0.43*** (40.44%) 7.10 ± 0.37** (28.75%)
MDHL (400 mg/kg) 3.87 ± 0.48 10.83 ± 0.59*** (62.52%) 10.98 ± 0.58*** (63.89%) 12.01 ± 0.73*** (73.12%) 8.48 ± 0.31*** (41.47%)
MDTL (200 mg/kg) 3.75 ± 0.22 5.57 ± 0.23 (16.14%) 7.59 ± 0.22** (34.13%) 9.83 ± 0.68*** (54.03%) 6.83 ± 0.32** (27.41%)
MDTL (400 mg/kg) 4.19 ± 0.25 7.99 ± 0.55*** (35.13%) 9.88 ± 0.52*** (52.63%) 12.15 ± 0.83*** (73.66%) 8.83 ± 0.53*** (42.93%)
MDCL (200 mg/kg) 3.86 ± 0.17 5.25 ± 0.30 (12.51%) 6.94 ± 0.66* (27.66%) 8.18 ± 0.30** (38.77%) 7.72 ± 0.53*** (34.69%)
MDCL (400 mg/kg) 4.34 ± 0.24 6.12 ± 0.20 (16.77%) 8.65 ± 0.59*** (40.49%) 10.09 ± 0.79*** (53.94%) 9.31 ± 0.32*** (46.62%)
MDEL (200 mg/kg) 3.88 ± 0.30 5.24 ± 0.24 (12.28%) 7.28 ± 0.20** (30.57%) 7.31 ± 0.38* (30.88%) 7.99 ± 0.37*** (37.04%)
MDEL (400 mg/kg) 4.63 ± 0.30 8.06 ± 0.44*** (33.05%) 9.15 ± 0.63*** (43.6%) 9.87 ± 0.40*** (50.55%) 10.43 ± 0.28*** (55.95%)
MDAL (200 mg/kg) 3.38 ± 0.80 5.72 ± 0.36 (20.12%) 9.62 ± 0.44*** (53.73%) 10.89 ± 0.39*** (64.62%) 12.62 ± 0.90*** (78.49%)
MDAL (400 mg/kg) 3.42 ± 0.18 6.71 ± 0.35** (28.42%) 11.03 ± 0.72*** (65.76%) 13.58 ± 0.43*** (87.71%) 13.79 ± 0.72*** (89.52%)
MDMS (200 mg/kg) 4.09 ± 0.38 6.43 ± 0.34 (21.43%) 8.77 ± 0.82*** (42.85%) 7.06 ± 0.63* (27.21%) 11.80 ± 0.55*** (70.65%)
MDMS (400 mg/kg) 4.09 ± 0.25 9.11 ± 0.44*** (45.95%) 10.89 ± 0.62*** (62.26%) 11.27 ± 0.61*** (65.79%) 13.88 ± 0.75*** (89.69%)
  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks