Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Future Journal of Pharmaceutical Sciences

Table 6 Analgesic activity of the investigated extracts of M. dispermus leaves and stem barks on tail immersion test

Group	Dose (mg/kg)	Percent (%) elongation of latency
Group	Dose (mg/kg)	30 min	60 min	90 min	120 min
Morphine sulfate	10	57.61	65.46	67.37	71.13
MDML 200	200	17.03	51.71	53.91	68.30
MDML 400	400	41.03	58.07	64.43	69.91
MDHL 200	200	41.95	50.68	44.67	41.67
MDHL 400	400	56.70	60.62	61.29	51.16
MDTL 200	200	15.77	43.03	52.71	39.36
MDTL 400	400	41.29	56.23	61.75	53.07
MDCL 200	200	10.70	37.68	43.15	46.34
MDCL 200	400	23.45	50.03	53.93	55.48
MDEL 400	200	10.60	40.59	36.43	48.19
MDEL 200	400	41.84	56.76	52.93	60.28
MDAL 400	200	17.98	55.06	57.31	67.15
MDAL 200	400	30.13	60.81	65.76	69.94
MDMS 200	200	27.14	50.70	34.20	64.88
MDMS 400	400	48.53	60.28	58.76	70.14

The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks