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Table 6 Analgesic activity of the investigated extracts of M. dispermus leaves and stem barks on tail immersion test

From: Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Group Dose (mg/kg) Percent (%) elongation of latency
30 min 60 min 90 min 120 min
Morphine sulfate 10 57.61 65.46 67.37 71.13
MDML 200 200 17.03 51.71 53.91 68.30
MDML 400 400 41.03 58.07 64.43 69.91
MDHL 200 200 41.95 50.68 44.67 41.67
MDHL 400 400 56.70 60.62 61.29 51.16
MDTL 200 200 15.77 43.03 52.71 39.36
MDTL 400 400 41.29 56.23 61.75 53.07
MDCL 200 200 10.70 37.68 43.15 46.34
MDCL 200 400 23.45 50.03 53.93 55.48
MDEL 400 200 10.60 40.59 36.43 48.19
MDEL 200 400 41.84 56.76 52.93 60.28
MDAL 400 200 17.98 55.06 57.31 67.15
MDAL 200 400 30.13 60.81 65.76 69.94
MDMS 200 200 27.14 50.70 34.20 64.88
MDMS 400 400 48.53 60.28 58.76 70.14
  1. The results were expressed in Mean ± SEM (standard mean error) *p < 0.05, **p < 0.01, and ***p < 0.001 were considered as statistically significant. The statistical analysis followed by one-way analysis of variance (Dunnett's test) compared to the control. MDML = Crude methanol extract of M. dispermus leaves, MDHL = n-hexane fraction of crude methanol extract of M. dispermus leaves, MDTL = Carbon tetrachloride fraction of crude methanol extract of M. dispermus leaves, MDCL = Chloroform fraction of crude methanol extract of M. dispermus leaves, MDEL = Ethyl acetate fraction of crude methanol extract of M. dispermus leaves, MDAL = Aqueous fraction of crude methanol extract of M. dispermus leaves, MDMS = Crude methanol extract of M. dispermus stem barks