Table 7 Analgesic effect of the investigated extracts of M. dispermus leaves and stem barks on formalin-induced paw licking test
Group | 0–5 min (early phase) | 15–30 min (late phase) | ||
|---|---|---|---|---|
Paw licking time (s) | Percent inhibition of pain | Paw licking time (s) | Percent Inhibition of PAIN | |
Control | 52.98 ± 4.73 | – | 72.76 ± 5.55 | – |
Morphine sulfate (10 mg/kg) | 8.71 ± 0.66*** | 83.55 | 4.90 ± 0.66*** | 93.27 |
MDML (200 mg/kg) | 23.72 ± 3.43** | 55.23 | 18.49 ± 1.23*** | 74.59 |
MDML (400 mg/kg) | 21.51 ± 3.83** | 59.40 | 12.57 ± 1.95*** | 82.72 |
MDHL (200 mg/kg) | 49.61 ± 8.07 | 6.37 | 43.65 ± 2.25*** | 40.02 |
MDHL (400 mg/kg) | 37.96 ± 6.82 | 28.35 | 18.27 ± 3.42*** | 74.89 |
MDTL (200 mg/kg) | 41.76 ± 3.63 | 21.18 | 28.17 ± 4.74*** | 61.29 |
MDTL (400 mg/kg) | 34.54 ± 6.81 | 34.81 | 12.20 ± 2.13*** | 83.23 |
MDCL (200 mg/kg) | 49.76 ± 5.05 | 6.08 | 29.70 ± 3.61*** | 59.18 |
MDCL (400 mg/kg) | 32.68 ± 4.05 | 38.31 | 25.43 ± 4.37*** | 65.05 |
MDEL (200 mg/kg) | 52.36 ± 6.69 | 1.17 | 14.98 ± 2.68*** | 79.41 |
MDEL (400 mg/kg) | 33.17 ± 4.87 | 37.39 | 8.87 ± 1.06*** | 87.80 |
MDAL (200 mg/kg) | 46.85 ± 5.20 | 11.58 | 63.95 ± 4.91 | 12.12 |
MDAL (400 mg/kg) | 29.71 ± 4.42* | 43.93 | 19.72 ± 3.08*** | 72.90 |
MDMS (200 mg/kg) | 45.97 ± 4.52 | 13.23 | 16.65 ± 2.26*** | 77.12 |
MDMS (400 mg/kg) | 24.21 ± 2.34** | 54.30 | 7.56 ± 0.62*** | 89.61 |