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Table 2 A brief overview of research work done on nanofibers for transdermal delivery of anti-inflammatory drugs

From: Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

S. No Drug Polymer Drug loading (%)/diameter (nm) Sophisticated techniques used for characterization/animal model used Key findings Ref
1 Naproxen Thermo plastic polyurethane Not given/523.66–723.50 SEM, FT-IR, TGA/not given Nanofibers composed of 10% (w/w) solution of thermoplastic polyurethane showed smooth texture and release of naproxen from nanofibrous mat was greatly affected by its thickness [69]
2 Plai oil Poly (lactic) acid 29.95 ± 1.25/0.38 µm SEM, FT-IR, TGA, DSC, XRD/not given Nanofibers containing 30% weight plai oil showed the highest in-vitro skin permeation in the reconstructed human epidermis (EpiSkin™) followed by minimum skin irritation indicating their suitability for transdermal delivery [70]
3 Diclofenac sodium Cellulose acetate Not given/0.5 µm Not given/not given Cellulose acetate based nanofibers showed uniform distribution of diclofenac sodium and high wettability followed by the release of only 30% diclofenac sodium during the first three hours of the release study [71]
4 Sulindac Polyvinyl alcohol-co-polyethylene 92/461 SEM, FT-IR, TGA, DSC/not given Sulindac loaded nanofibers showed high drug loading, in-vitro stability followed by high in-vitro skin permeation of sulindac compared to patch available in the market [72]
5 Tetrahydro curcumin Poly caprolactone, polyethylene glycol 95/400 ± 20 SEM, FT-IR, TGA, DSC, XRD/not given Nanofibers composed of polycaprolactone (10% w/v) and polyethylene glycol (5% w/v) in a 2:1 ratio showed excellent morphology and high in-vitro shear adhesion followed by the extended in-vitro release of tetrahydro curcumin for 24 h [73]