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Table 3 Intra- and inter-day precision and accuracy results (n = 6)

From: Design of experiment-driven stability-indicating RP-HPLC method for the determination of tofacitinib in nanoparticles and skin matrix

Sample

Intraday precision

Accuracy

QC

Experimental concentration (µg/mL)

% Recovery ± SD

% RSD

% Bias

LQC

252.06 ± 4.32

100.81 ± 1.73

1.1666 ± 0.019

0.818 ± 0.39

MQC

7847.82 ± 192.2

98.09 ± 1.52

1.7295 ± 0.0423

1.908 ± 0.20

HQC

11,781.5 ± 213.9

98.17 ± 1.25

1.2827 ± 0.023

1.827 ± 0.56

 

Interday precision

   

LQC

252.06 ± 4.32

100.82 ± 1.44

1.6498 ± 0.027

0.824 ± 0.39

MQC

7915.25 ± 96.84

98.94 ± 1.35

1.2219 ± 0.014

1.059 ± 0.20

HQC

11,797.79 ± 212.75

98.31 ± 1.43

1.8017 ± 0.032

1.685 ± 0.43

  1. LQC: 250 ng/mL; MQC: 8000 ng/mL; HQC: 12,000 ng/mL