Table 4 Stability results of tofacitinib in forced degradation study
Study performed | Stress condition | % of Tofacitinib degraded | Degradation peaks with retention time (min) |
|---|---|---|---|
Acid hydrolysis | 0.5 M Hydrochloric acid | 14.78 ± 0.04% | 3.67, 3.8 and 4.6 |
Base hydrolysis | 0.5 M sodium hydroxide | 75 ± 0.06% | 5.4 |
Oxidative | 2% hydrogen peroxide | 20.25 ± 0.04% | 3.7 and 4.6 |
Thermal | Water | 1.5 ± 0.02% | – |