Table 5 Statistical summary of ANOVA for response surface design
From: Response surface method for optimization of prepared satranidazole powder layered pellets
Response | F-value | p Value | R2 | Adjusted R2 | Predicted R2 | ||||
|---|---|---|---|---|---|---|---|---|---|
Model | X1: Ratio of coating mixture (%) | X2: Coating level (%) | Model | X1: Ratio of coating mixture (%) | X2: Coating level (%) | ||||
% Drug release at 2 h (Y1) | 9.845 | 0.0381 | 19.653 | 0.0021 (S) | 0.848 (NS) | 0.0006 (S) | 0.584 | 0.525 | 0.287 |
% Drug release at 6 h (Y2) | 5.704 | 2.447 | 8.962 | 0.0154 (S) | 0.1401 (NS) | 0.0097 (S) | 0.449 | 0.370 | 0.077 |
% Drug release difference in presence & absence of colonic enzyme at 10 h (Y3) | 9.771 | 7.547 | 11.996 | 0.0022 (S) | 0.0157 (S) | 0.0038 (S) | 0.582 | 0.523 | 0.270 |
Mean dissolution time (Y4) | 2.751 | 1.669 | 3.833 | 0.0982 (S) | 0.2172 (NS) | 0.0705 (S) | 0.282 | 0.179 | 0.182 |