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Table 5 Statistical summary of ANOVA for response surface design

From: Response surface method for optimization of prepared satranidazole powder layered pellets

Response F-value p Value R2 Adjusted R2 Predicted R2
Model X1: Ratio of coating mixture (%) X2: Coating level (%) Model X1: Ratio of coating mixture (%) X2: Coating level (%)
% Drug release at 2 h (Y1) 9.845 0.0381 19.653 0.0021 (S) 0.848 (NS) 0.0006 (S) 0.584 0.525 0.287
% Drug release at 6 h (Y2) 5.704 2.447 8.962 0.0154 (S) 0.1401 (NS) 0.0097 (S) 0.449 0.370 0.077
% Drug release difference in presence & absence of colonic enzyme at 10 h (Y3) 9.771 7.547 11.996 0.0022 (S) 0.0157 (S) 0.0038 (S) 0.582 0.523 0.270
Mean dissolution time (Y4) 2.751 1.669 3.833 0.0982 (S) 0.2172 (NS) 0.0705 (S) 0.282 0.179 0.182
  1. *Significant and non-significant value indicates by S and NS