Table 2 Solubility studies of ATS and VIN in solid lipids, surfactant, co-surfactant and combination of solid lipids
Solid lipids | ATS solubility (mg/gm) | VIN solubility (mg/gm) |
|---|---|---|
Cetyl palmitate | 5.99 | 0.60 |
Stearic acid | 2.53 | 1.78 |
Emulcire | 10.27 | 1.07 |
Gelucire | 23.57 | 2.28 |
Compritol 888 | 26.12 | 2.42 |
Precirol ATO 5 | 27.83 | 3.67 |
GMS | 34.16 | 6.52 |
Surfactant, co-surfactant (mg/2 ml) | ||
Tween 20 | 6.40 | 55.30 |
Tween 80 | 10.4 | 19.53 |
Span 20 | 9.00 | 19.38 |
Span 80 | 12.37 | 11.37 |
Triton × 100 | 9.06 | 40.96 |
Labrasol | 65.14 | 69.2 |
Poloxamer 188 | 7.01 | 1.681 |
Poloxamer 407 | 5.26 | 7.11 |
Ratio | Compritol 888 + Precirol ATO 5 | GMS + Precirol ATO 5 |
|---|---|---|
ATS solubility (mg/gm) | ||
1:01 | 0.46 | 15.85 |
1:03 | 0.85 | 9.84 |
3:01 | 0.60 | 25.54 |
VIN solubility (mg/gm) | ||
1:01 | 0.93 | 10.56 |
1:03 | 1.15 | 5.52 |
3:01 | 0.83 | 16.02 |