Development, optimization, and in vitro evaluation of atorvastatin calcium and vinpocetine codelivery by solid lipid nanoparticles for cancer therapy

Future Journal of Pharmaceutical Sciences

Table 5 Model analysis and model fitted statistical values

CQA parameters	Model suggested	Model significance value	Lack of fit value	R² value	Model's mathematical equation
Particle Size	Quadratic model	< 0.0001	2628.2	0.974	398.12 + 45.48 * A − 38.62 * B − 7.51 * C − 27.13 * AB − 14.38 * AC + 2.62 * BC + 35.29A² + 2.90 * B² + 44.13 * C²
% EE (ATS)	Cubic model	0.0214	34.53	0.924	54.89 + 0.9656 * A + 3.84 * B − 1.20 * C − 0.1963 * AB + 2.10 * BC + 0.5081 * A² + 0.663 * B² − 1.97 * C²
% EE (VIN)	Cubic model	< 0.0001	0.0390	0.999	57.5 + 1.33 * A + 3.18 * B − 1.47 * C + 3.06 * AB + 1.03 * AC + 5.83 * BC − 2.11 * A² + 0.2684 * B² − 5.64 * C²
% DL	Quadratic model	< 0.0001	1.24	0.951	5.54–1.20 * A + 0.365 * B − 0.149 * C 0.0288 * AB + 0.1512 * AC + 0.3037 * BC + 0.2003A² + 0.0889 * B² − 0.238 * C²

EE, entrapment efficiency; DL, drug loading; A, drug lipid ratio; B, surfactant co surfactant ratio; C, homogenization speed