Skip to main content

Table 7 Results for forced degradation studies

From: Stability indicating RP-UPLC method for simultaneous quantification of bempedoic acid and ezetimibe in bulk and pharmaceutical formulations

Degradation study *Assay (%w/w) % Degradation Tailing factor Theoretical plates
BA EZ BA EZ BA EZ BA EZ
Control 99.90 99.90 - - 1.156 1.137 3679 7935
Acidic 99.17 99.31 0.73 0.59 1.183 1.277 4129 8367
Alkaline 99.26 99.42 0.64 0.48 1.294 1.248 3934 8753
Peroxide 99.48 99.30 0.46 0.59 1.150 1.342 4352 8243
Thermal 99.05 99.20 0.85 0.69 1.184 1.069 4253 7961
Photolytic 99.62 99.67 0.28 0.23 1.215 1.283 4472 8452
  1. *Mean of three determinations; BA = Bempedoic acid; EZ = Ezetimibe