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Table 7 Results for forced degradation studies

From: Stability indicating RP-UPLC method for simultaneous quantification of bempedoic acid and ezetimibe in bulk and pharmaceutical formulations

Degradation study

*Assay (%w/w)

% Degradation

Tailing factor

Theoretical plates

BA

EZ

BA

EZ

BA

EZ

BA

EZ

Control

99.90

99.90

-

-

1.156

1.137

3679

7935

Acidic

99.17

99.31

0.73

0.59

1.183

1.277

4129

8367

Alkaline

99.26

99.42

0.64

0.48

1.294

1.248

3934

8753

Peroxide

99.48

99.30

0.46

0.59

1.150

1.342

4352

8243

Thermal

99.05

99.20

0.85

0.69

1.184

1.069

4253

7961

Photolytic

99.62

99.67

0.28

0.23

1.215

1.283

4472

8452

  1. *Mean of three determinations; BA = Bempedoic acid; EZ = Ezetimibe