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Table 4 Results of forced degradation studies

From: New stability indicating RP-HPLC-PDA method for determination of mifepristone in bulk and tablet formulation

Degradation condition Procedure Observation % degradant found
Acid hydrolysis 0.1 N Methanolic HCl reflux at 70 °C for 3 h Degradant observed 24.12
Base hydrolysis 0.5 N Methanolic NaOH reflux at 70 °C for 5 h Degradant observed 9.75
Oxidative 12% H2O2 at room temperature for 8 h Degradant observed 5.21
Thermal (dry heat and wet heat) Solution kept in hot air oven at 80 °C for 8 h No degradant observed
Photolytic Drug exposed to direct sunlight for 7 days No degradant observed