Table 3 Composition of different formulations of Glimepiride and Pioglitazone pellets
Ingredients | Formulation Batches | ||||||||
|---|---|---|---|---|---|---|---|---|---|
B1 | B2 | B3 | B4 | B5 | B6 | B7 | B8 | B9 | |
Glimepiride (mg) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
Pioglitazone (mg) | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 |
Lactose monohydrate (Pharmatose 200 M) (mg) | 80.0 | 80.0 | 92.5 | 92.5 | 63.5 | 96.5 | 96.5 | 63.5 | 92.5 |
Microcrystalline cellulose (mg) | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 |
Sodium starch glycolate (Primogel) (mg) | 2.5 | 2.5 | 2.5 | 1.0 | 5.0 | 1.0 | 5.0 | 1.0 | 5.0 |
Tween 80 (mg) | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Purified water (mL) | 3.0 | 3.0 | 3.5 | 3.5 | 2.8 | 3.6 | 3.6 | 2.8 | 3.5 |